In a groundbreaking development poised to advance research in biology, medicine, neuroscience, and nanoscience, scientists at the Raman Research Institute (RRI) have designed an innovative dual-trap optical tweezers system—a crucial tool for manipulating microscopic particles with light. This home-grown solution, developed by a team led by Dr. Pramod A Pullarkat, addresses long-standing limitations of traditional designs and is set to make high-precision experiments more accessible, reliable, and affordable for Indian researchers.
Optical tweezers, which earned the 2018 Nobel Prize in Physics, use focused laser beams to trap and manipulate extremely small objects such as biomolecules. Dual-trap systems, which use two laser beams to hold and study interactions between particles, are essential in measuring tiny forces at the molecular level. However, conventional setups face major challenges including signal interference (cross-talk), complexity, and integration issues with existing microscopy systems.
RRI researchers have overcome these hurdles by creating a novel confocal detection system that senses backward-scattered light from each individual trap. This design ensures that each laser trap functions independently, eliminating interference and maintaining perfect alignment even during movement. The result is a highly stable, modular system that integrates seamlessly with standard microscopes and supports advanced imaging methods like fluorescence or phase contrast microscopy.
“This new single-module system allows for precise force measurement of single molecules, easier probing of soft biological materials, and micromanipulation of cells—all without the need for expensive or bulky components,” said Md Arsalan Ashraf, PhD scholar at RRI.
Beyond scientific excellence, the design also holds strong potential for patent protection and commercialization. The team is now working toward launching this plug-and-play module for widespread use in research labs, enhancing India’s capabilities in cutting-edge science and technology.
This innovation marks a major step in democratizing high-end scientific tools, empowering researchers across India to explore new frontiers in molecular and cellular biology, nanotechnology, and drug development.
