February 19, 2025

First Nasal Vaccine Against COVID- 19 Supported by DBT-BIRAC gets Emergency Use Authorization

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PIB Delhi – Department of Biotechnology (DBT) and its PSU, Biotechnology Industry Research Assistance Council (BIRAC) is delighted to announce approval from DCGI for emergency use authorization first of its kind intranasal COVID-19 Vaccine to Bharat Biotech (BBIL). Supported by DBT and BIRAC under the aegis of Mission COVID Suraksha, the mission was launched by DBT and implemented by BIRAC to reinforce and accelerate COVID-19 vaccine development efforts as part of Aatmanirbhar 3.0. Scientific leadership at various levels of vaccine development was provided by DBT laboratories and BIRAC. This is the fourth success story for the Covid-19 vaccine under mission Covid Suraksha.

BBV154 is an intranasal replication-deficient chimpanzee adenovirus SARS-CoV-2 vectored vaccine. It consists of a replication deficient ChAd vector expressing the stabilized Spike SARS-CoV-2 (Wuhan variant). DBT’s Autonomous Institute, National Institute of Immunology (NII), New Delhi utilized their “Human Immune Monitoring and T-cell Immunoassay Platform” to examine the vaccine-induced SARS-CoV-2-specific systemic and mucosal cellular immune responses the trial participants. Interactive Research School for Health Affairs (IRSHA), Pune completed the Plaque Reduction Neutralization Assay (PRNT) to quantify the titer of neutralizing antibody for the virus from three trial sites.

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